P2X Receptor
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P2X Receptor Produits associés (73)
Produits associés (73)
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2-Methylthio-ATP tetrasodium
0 Images2-Methylthio-ATP tetrasodium is a non-specific P2-receptor agonist. 2-Methylthio-ATP tetrasodium causes noncompetitive inhibition of ADP-induced human platelet aggregation.
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7DG
0 ImagesSynonyms: 7-Desacetoxy-6,7-dehydrogedunin7DG (7-Desacetoxy-6,7-dehydrogedunin) is a PKR inhibitor, P2X7 purinergic receptor inhibitor, and skin-lightening agent. 7DG binds outside the ATP-catalytic domain of PKR, blocks the kinase activity-independent protein-protein interactions of PKR, inhibits the phosphorylation and activity of PKR, disrupts ASC assembly and caspase-1 activation, and suppresses the activation of the NLRP1 inflammasome. 7DG inhibits pyroptosis, suppresses the ATP-P2X7 signaling pathway, and abolishes ATP-induced increases in the expression levels of MITF, tyrosinase, PMEL/gp100, and melanin content. 7DG exerts skin-lightening effects in cultured skin in vitro. 7DG can be used in research related to chronic obstructive pulmonary disease, gout, type 2 diabetes, Alzheimer's disease, and hyperpigmentary skin disorders.
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P2X7-IN-2 TFA
0 ImagesCat. No.: HY-18725APureté: 99.93%P2X7-IN-2 TFA (compound 58) is a P2X7 receptor inhibitor. P2X7-IN-2 TFA inhibits IL-Iβ release with an IC50 value of 0.01 nM. P2X7-IN-2 TFA can be used for the research of autoimmunity, inflammation and cardiovascular disease.
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P2X7-IN-2
0 ImagesCat. No.: HY-18725CAS No.: 1058709-63-9P2X7-IN-2 (compound 58) is a P2X7 receptor inhibitor. P2X7-IN-2 inhibits IL-Iβ release with an IC50 value of 0.01 nM. P2X7-IN-2 can be used for the research of autoimmunity, inflammation and cardiovascular disease.
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MRS4719-d3
0 ImagesCat. No.: HY-151547SMRS4719-d3 is the deuterium labeled MRS4719 (HY-151547). MRS4719 is a potent P2X4 receptor antagonist with an IC50 value of 0.503 μM for human P2X4 receptor. MRS4719 can reduce infarct volume and reduce brain atrophy, showing neuroprotective and neuro-rehabilitative activities in ischemic stroke model. MRS4719 also reduces ATP-induced [Ca2+]i influx in primary human monocyte-derived macrophages. MRS4719 can be used to research ischemic stroke.
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AF-353 hydrochloride
0 ImagesCat. No.: HY-14483ACAS No.: 927887-18-1Synonyms: Ro-4 hydrochlorideAF-353 hydrochloride is a potent, selective and orally bioavailable P2X3/P2X2/3 receptor antagonist, with a pIC50 of 8.0 for both human and rat P2X3, and with a pIC50 of 7.3 for human P2X2/3.
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Purotoxin 1
0 ImagesCat. No.: HY-P1330CAS No.: 1396322-38-5Purotoxin 1 is a P2X3 receptor inhibitor. Purotoxin 1 shows antinociceptive properties in animal models of inflammatory pain. Purotoxin 1 can be isolated from the venom of the wolf spider Geolycosa sp.
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NF864
0 ImagesCat. No.: HY-130284CAS No.: 69606-09-3NF864 is a selectivelyP2X1 receptorinhibitor in human platelets.
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MRS4596
0 ImagesCat. No.: HY-151546CAS No.: 2840581-38-4MRS4596 is a potent and selective P2X4 receptor antagonist with an IC50 value of 1.38 μM for human P2X4 receptor. MRS4596 has neuroprotective and neuro-rehabilitative activities in ischemic stroke model. MRS4596 can be used in research of ischemic stroke .
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Iso-PPADS tetrasodium
0 ImagesCat. No.: HY-101077CAS No.: 207572-67-6Iso-PPADS tetrasodium is a P2X-purinoceptor antagonist. Iso-PPADS tetrasodium inhibits P2X1 and P2X3 receptor with IC50s of 43 nM and 84 nM. Iso-PPADS tetrasodium is protective against ventilator-induced brain injury (VIBI).
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MSK-9
0 ImagesCat. No.: HY-176731MSK-9 is a positive allosteric modulator of the P2X4 receptor with dual activities of enhancing ion conductance and delaying receptor inactivation. MSK-9 stabilizes the open state of the P2X4 receptor through rigid 3-piperidinyl and hydrophobic menthyl substituents. MSK-9 can be used in the study of multiple sclerosis (MS).
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JNJ-54166060
0 ImagesCat. No.: HY-124300CAS No.: 1627900-41-7JNJ-54166060 is a potent and selective P2X7 receptor antagonist, with IC50s of 4/115/72 nM for human/rat/mouse P2X7 receptor, respectively.
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H-Lys-Tyr-OH TFA
0 ImagesCat. No.: HY-134458ASynonyms: Lysyltyrosine TFAH-Lys-Tyr-OH TFA (Lysyltyrosine TFA) is a dipeptide composed of lysine and tyrosine. H-Lys-Tyr-OH TFA prevents neurological diseases or improves brain function by promoting the release of noradrenaline and tyrosine into the brain.
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MRS4719
0 ImagesCat. No.: HY-151547CAS No.: 2840581-32-8MRS4719 is a potent P2X4 receptor antagonist with an IC50 value of 0.503 μM for human P2X4 receptor. MRS4719 can reduce infarct volume and reduce brain atrophy, showing neuroprotective and neuro-rehabilitative activities in ischemic stroke model. MRS4719 also reduces ATP-induced [Ca2+]i influx in primary human monocyte-derived macrophages. MRS4719 can be used to research ischemic stroke.
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MRS4596-d4
0 ImagesCat. No.: HY-151546SMRS4596-d4 is the deuterium labeled MRS4596 (HY-151546). MRS4596 is a potent and selective P2X4 receptor antagonist with an IC50 value of 1.38 μM for human P2X4 receptor. MRS4596 has neuroprotective and neuro-rehabilitative activities in ischemic stroke model. MRS4596 can be used in research of ischemic stroke.
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Relicpixant
0 ImagesCat. No.: HY-159832CAS No.: 2445366-94-7Relicpixant is a potent purinoreceptor (P2X) antagonist.
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P2X3 antagonist 37
0 ImagesCat. No.: HY-143576CAS No.: 2649318-40-9P2X3 antagonist 37 is a potent P2X3 receptor antagonist with an IC50 of 32.45 nM for hP2X3 (WO2021115225A1, example 68).
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Ro-51
0 ImagesCat. No.: HY-14485CAS No.: 1050670-85-3Ro-51 is a potent and selective dual P2X3/P2X2/3 antagonist, with IC50 of 2 nM and 5 nM for P2X3 and P2X2/3, respectively. Ro-51 can be used for the research for pain.
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P2X3 antagonist 36
0 ImagesCat. No.: HY-143568CAS No.: 2310263-59-1P2X3 antagonist 36 is a P2X3 antagonist extracted from patent WO2019081343A1 compound 156.
